Advancing Mitochondrial Science
The framework behind Mitome is built on a rigorous analysis of peer-reviewed scientific literature. While the specific interpretive model we use is proprietary and original, and also based on in-house analysis of the underlying test cross-referenced with comprehensive genomic and biochemical data, it is fundamentally grounded in decades of research on mitochondrial bioenergetics, nutrient biochemistry, and cellular metabolism.
What you’ll find below is not a list of studies conducted directly by our team, but rather the foundational research that informed the development of our methodology. We’ve taken what was once a test used almost exclusively for rare disease diagnosis and re-engineered its application to make it actionable for anyone seeking to optimize health, performance, and longevity at the cellular level.
This page is designed for transparency and scientific accountability—to show how we've built on the existing body of evidence to bring mitochondrial analysis into a new era of practical, personalized health optimization.

Featured Publications
Explore the research and insights advancing mitochondrial science and health.
Rapamycin rescues mitochondrial dysfunction in cells carrying the m.8344A > G mutation in the mitochondrial tRNALys
Published BySpringer Science and Business Media LLCAugust 3, 2022August 3, 2022Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation
Published ByElsevier BVOctober 11, 2013October 11, 2013Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism
Published ByBioscientificaJanuary 1, 2010January 1, 2010Rapamycin enhances survival in a Drosophila model of mitochondrial disease.
Published ByOncotargetDecember 6, 2016December 6, 2016mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome
Published ByAmerican Association for the Advancement of Science (AAAS)December 20, 2013December 20, 2013Rapamycin as a potential treatment for succinate dehydrogenase deficiency
Published ByElsevier BVFebruary 11, 2019February 11, 2019Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease
Published ByOxford University Press (OUP)September 1, 2015September 1, 2015Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes: Role of autophagy in mitochondrial dysfunction
Published ByWileyApril 1, 2015April 1, 2015

Partner with Mitome™
Join the front lines of a revolution in health. We’re fighting back against decline, burnout, and biological guesswork — and we’re looking for partners who want to do the same.
Reach out to us at support@mito.me to explore affiliate and collaboration opportunities.