Decoding the Science of Cellular Energy

We translate complex mitochondrial science into clear, actionable insights that transform human health and longevity. No more guessing - discover exactly what your mitochondria need to thrive.

Mitochondrial Testing Kit | Mitome
Cellular Health for Optimal Energy
Mitochondria Test

Testing Guide: Unlock Your Cellular Potential

Four steps to optimize your mitochondrial health.

The Process is Simple

1

Order Your Test

Your comprehensive kit arrives at your door, complete with everything you need.

2

Complete Your Form.

Fill out the requisition form by providing your name, date of birth, and signature.

3

Quick Sample Collection

A simple 5-minute buccal cheek swab you can do at home. No blood draws, no clinics. Simply freeze the icepacks and ship it right out.

View Collection Instructions
4

Receive Your Personalized Protocol

Within 3-5 weeks, unlock your unique mitochondrial pattern and optimization strategy.

View Sample Report
Mitochondrial Testing Kit | Mitome
Cellular Health for Optimal Energy
Mitochondria Test
Easy 5-minute buccal cheek swab you can do in the comfort of your home

Mitome Kit

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What Your Analysis Reveals

Through advanced analysis of your electron transport chain activity, we uncover your unique cellular blueprint and exact optimization pathways.

mitochondrial health and biomarker testing
  • Complete Mitochondrial Analysis

  • Science Behind Your Action Plan

  • Evidence-Based Recommendations

  • Specific Energy Production Bottlenecks

  • Personalized Food and Supplement Protocol

  • Clear Path to Peak Performance

How We Measure

Our breakthrough technology maps your unique mitochondrial pattern - something no blood test, genetic screen, or hormone panel can reveal.

Our comprehensive mitochondrial analysis measures five key cellular components that reveal how efficiently your cells produce energy:

01

Citrate Synthase Activity

We measure this critical enzyme from the citric acid cycle, which serves as a reliable indicator of your mitochondrial density. This tells us whether your body is producing enough mitochondria to meet your energy demands, or if it's working overtime to compensate for energy gaps.

02

Four Respiratory Chain Complexes

We analyze each of the four major energy-producing complexes (Complex I, II, II+III, and IV) individually.

This detailed breakdown allows us to:Identify which specific nutrients each complex needs for optimal performance

  • Determine if bottlenecks in particular complexes require adjustments to your protein, carbohydrate, or fat intake

  • Detect precise biochemical patterns that reveal exactly what's limiting your energy production

This multi-layered approach gives us a complete picture of your cellular energy system—like having a detailed assessment of each component of your body's power grid. The result is targeted recommendations that address your specific energy production challenges, not generic advice.

Advanced Mitochondrial Pattern Analysis

Our revolutionary process transforms complex cellular data into clear, actionable protocols.

How does the actual protocol optimize the mitochondria?

Your mitochondria—the powerhouses of your cells—need the right nutrients and signals to produce energy efficiently. Our advanced testing uses sophisticated pattern analysis to identify exactly what your mitochondria are missing. The test reveals which essential nutrients are depleted and which regulatory pathways aren't functioning optimally. Based on these personalized insights, we provide targeted nutritional support and specific factors that activate the correct cellular pathways, restoring your mitochondria to peak performance. Think of it as giving your cellular engines exactly the fuel and maintenance they need to run at full capacity—resulting in increased energy, better recovery, and enhanced overall vitality.

How Our Method Works (And Why It's Not Genetic Testing)
  • While 297 genes directly impact your mitochondrial respiratory chain—each with potentially dozens of mutations and variations—genetic testing has significant limitations. DNA analysis is complex, expensive, and can only tell you what might happen or explain what has happened. Most importantly, genetics can't tell you what's actually happening in your body right now.

  • That's why we use direct biochemical analysis instead. Our method evaluates each complex of your respiratory chain in real-time, measuring actual cellular function rather than genetic potential.

  • Here's the key advantage: Rather than sorting through hundreds of genetic variables, our advanced pattern analysis identifies the specific bottlenecks limiting your mitochondrial performance. This targeted approach quickly pinpoints exactly what your cells need to optimize energy production—giving you actionable results based on your body's current state, not just genetic possibilities.

Stylized chemical structure representing mitochondrial function and cellular energy production

The Results?

Faster, more accurate insights that lead to immediate, personalized optimization strategies tailored to your unique mitochondrial profile.

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Featured Publications

Explore the research and insights advancing mitochondrial science and health.

  • Performance and Longevity

    Optimize your cellular energy production for peak performance. Research shows mitochondrial nutrients significantly impact exercise performance and recovery, while mitochondrial decline (1% annually) directly influences aging.

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    Ostojic SM. Mitochondria-targeted nutraceuticals in sports medicine: a new perspective. Res Sports Med [Internet]. Informa UK Limited; 2017 Jan [cited 2025 Jan 4];25(1):91–100. Available from: https://pubmed.ncbi.nlm.nih.gov/27855498/ PMID: 27855498

    Guo Y, Guan T, Shafiq K, Yu Q, Jiao X, Na D, Li M, Zhang G, Kong J. Mitochondrial dysfunction in aging. Ageing Res Rev [Internet]. Elsevier BV; 2023 Jul [cited 2025 Jan 4];88(101955):101955. Available from: https://pubmed.ncbi.nlm.nih.gov/37196864/ PMID: 37196864

    Read More
  • Energy and Cellular Optimization

    Breakthrough research has revealed mitochondrial dysfunction as a key factor in chronic fatigue and energy-related conditions. Our analysis targets these fundamental cellular mechanisms.

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    Recent studies demonstrate that mitochondrial dysfunction plays a central role in chronic fatigue syndrome (ME/CFS), revealing the critical connection between cellular energy production and overall vitality. Our approach directly addresses these cellular mechanisms.

    Booth NE, Myhill S, McLaren-Howard J. Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Int J Clin Exp Med [Internet]. Int J Clin Exp Med; 2012 Jun 15 [cited 2025 Jan 4];5(3):208–220. Available from: https://pubmed.ncbi.nlm.nih.gov/22837795/ PMCID: PMC3403556

    Read More
  • Cognitive Function and Mental Health

    Groundbreaking research reveals the critical role of mitochondrial health in cognitive function and mental well-being. Studies show Alzheimer's brains have ten times the mitochondrial DNA damage compared to healthy brains

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    Studies have uncovered that mitochondrial function is fundamental to brain health, with dysfunction linked to various neurological and mental health conditions. Research demonstrates mitochondrial health's crucial role in autism spectrum disorders, schizophrenia, bipolar disorder, and depression.

    • Wang W, Zhao F, Ma X, Perry G, Zhu X. Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances. Mol Neurodegener [Internet]. Springer Science and Business Media LLC; 2020 May 29 [cited 2025 Jan 4];15(1):30. Available from: https://pubmed.ncbi.nlm.nih.gov/32471464/ PMCID: PMC7257174
    • Kim Y, Vadodaria KC, Lenkei Z, Kato T, Gage FH, Marchetto MC, Santos R. Mitochondria, metabolism, and redox mechanisms in psychiatric disorders. Antioxid Redox Signal [Internet]. Antioxid Redox Signal; 2019 Aug 1 [cited 2025 Jan 4];31(4):275–317. Available from: https://pubmed.ncbi.nlm.nih.gov/30585734/ PMCID: PMC6602118
    Read More

Transformative Results

Learn how advanced mitochondrial analysis has helped others enhance their energy, performance, and longevity.

"I don’t even know where to begin, but maybe “thank you” is a good start...

For several years, I had been experiencing on/off health problems that I didn’t initially think were serious issues—a constellation of seemingly disconnected problems. It started with digestive problems and eventually became more serious—including PVCs and tachycardia episodes that doctor’s initially believed were SVT episodes.

The latter didn’t happen very often, but would under certain conditions. Having extra sodium in my diet seemed to help somewhat, but I knew something wasn’t normal. I just didn’t know what.

I was also having trouble recovering from my training (weightlifting) and even just long walks with the dog. I would take excessively long naps (3-4hrs) during the day because I was so exhausted, I couldn’t keep my eyes open, and (oddly enough) had trouble sleeping through the night. I never felt truly rested. Over time, I started developing infrequent PVCs, which went from being infrequent to frequent.

It all came to a head last April (2025) when I was rushed to the ER after a tachycardia episode during a routine morning walk where I experienced a sustained heart rate of 190 bpm for 20-25 minutes. Heart was fluttering and by the time I got to the ER, I was barely able to stand. As soon as they administered saline, I converted instantly to normal sinus rhythm.

After that event, echocardiogram performed at my cardiologist’s office and MyZio (heart monitor worn for 2 weeks) confirmed PACs and frequent VE/PVCs at 72,289 isolated events over a period of 2 weeks. No other structural problems, aFib or any other problems, but it was distressing enough.

I was scared out of my mind, thought I was surely going to die, and no doctor could offer me any advice except medication to control them or potentially ablation surgery if the SVT came back. They assured me everything was going to be OK and it wasn’t life-threatening, but I knew this wasn’t normal for me. I’ve never been this way, and I spent considerable time and energy trying to stay active and eat healthy. But, in spite of my efforts, there were issues I seemed unable to control, like an expanding waistline, frequent aches and pains, and random, seemingly unexplainable and disconnected, nagging issues that didn’t seem to have any obvious solution and which no doctor had any meaningful or helpful insight or opinion about.

In the fall, I discovered your Mitome service and gave it a shot. I wasn’t getting any real answers elsewhere, and the digestive distress and PVCs were driving me insane. You had mentioned digestive upset potentially being linked to mitochondrial health. At that point, I had little to lose and everything to gain. I was told to just live with the PVCs, so I wrote them off as “this is just how it is now”.

Mitome results showed my complex II+III was functioning at 11%. Initial morning fasting lactate levels were 3.4 mmol/L. I can only guess what they spiked to during the day or strenuous (or even mild) physical activity. I followed the steps in my report and eventually my lactate levels came way down—not immediately but eventually it did come down. To my surprise I discovered multiple nutritional deficiencies as well, in spite of eating a nutrient-dense diet.

The protocol seemed to have a positive effect within 3-4 days, dropping my lactate levels in the mid 2s. Higher supplementation caused further drops until I hit 1.5. Correcting/working on correcting those nutritional deficiencies seems to have further improved this, dropping lactate below 1 mmol/L.

But… one of the more interesting things (to me, anyway) is once my lactate levels dropped below 2mmol/L, the PVCs stopped completely. I also haven’t had another tachycardia episode. I don’t feel the same sense of dread as I did before. I’m not fearful or scared to push myself to my limits. Lactate levels now are stabilized below 1, with occasional spikes up to 1.2 or 1.5.
Digestion is completely normalized—I feel like I can eat anything, including high FODMAP foods, without any digestive distress. I don’t need digestive bitters or enzymes at all, whereas before… I relied on both for even small meals, and still faced some digestive upset afterwards. And without the enzymes and bitters, it was even worse.

It also used to be that I was unable to eat eggs (or could only eat them very very sparingly) due to extremely painful digestive upset afterwards. Now I can eat as many eggs as I want, which is great because I love eggs and have at least 2 of them every day.
I sleep like a rock now, and feel recovered every morning, even on the occasional days when I don’t get a full 8 hours. Before, I slept (very poorly) for 10 hours at night and woke up tired. Now I sleep 7-8 hours and wake up feeling amazing.

I’m recovering from workouts and back to making progress in the gym. I’ve lost about 10lbs (give or take), my waistline has decreased from 40” to 35” (and counting), and yet… the weight on the bar keeps increasing and I keep getting stronger. I’ve even set some new all-time PRs in the gym on some difficult (for me) lifts.

I’m not the type of person to believe in miracles, but I can’t think of a better word to describe it—it’s “miraculous”. I feel like a new man. I’m sure there some more things I can improve, but even now… I have an entirely new perspective on, and renewed enthusiasm for, life. Before, it seemed hopeless. Now, I feel like I can do anything.

You’ve given me my life back. That is a debt I cannot repay. Thank you again for everything you’re doing with Mitome, and the continuing education around mitochondrial health.

If you have ever wondered whether you are really making a difference in anyone’s life, don’t. You are. Please keep up the great work.

Thank you, again."

David Lewis testimonial - improved mitochondrial health and eliminated PVCs with Mitome test

David Lewis

"I went into unexplained menopause at 28 years old for ten years, and nothing could restore my ability to menstruate without medication or hormone treatment. I tried everything, unsuccessfully—  conventional medicine, functional medicine, homeopathy, alternative therapies, diet and fitness changes, you name it.Just two weeks after trying one supplement Chris identified from my cheek swab as critical for my mitochondrial health, I began menstruating again. 100% true story."

Real testimonials about mitochondrial function testing results and improved cellular energy and health outcomes.

Jacqueline R.

"Very in-depth info on much of what is important for health… Here one gets insights that one cannot find in other places and that is approached from different angles."

Happy customer after Mitome mitochondrial function test improved cellular energy and mitochondrial health through biomarker testing

Alphonse Van C.

"I have been struggling with severe episodes of reflux, extreme fatigue and stomach issues that have been getting worse and worse in the past few years. I was really starting to lose hope until I stumbled upon Dr Chris Masterjohn's work. I found out from the analysis that I had mitochondrial dysfunction affecting my cellular energy production, but it was something that could be fixed with targeted supplementation. The mitochondrial support I received has changed my life. I now can eat food and actually feel energized afterwards as my cells are properly converting nutrients into energy, it has made life so much more rewarding and fulfilling and I cannot thank Chris enough!"

Satisfied Mitome customer celebrating biomarker testing results that improved mitochondrial function and cellular energy production

Michael Connolly

"For a year after chemotherapy, I struggled with deep fatigue, brain fog, and scars that did not heal completely. This was the first time I found someone who looked at my issues as a mitochondrial dysfunction problem. Dr. Masterjohn suggested what I could do to test certain mitochondrial pathways that might be impaired based on the Mitome test results. These included diet changes to support cellular energy production, specific supplements targeting mitochondrial function, and therapy to boost mitochondrial activity. The resulting surge in cellular energy allowed me to start a strength training program, replacing muscle lost to muscle atrophy from chemotherapy. Scarring from treatment that was static for over a year completed healing and autoimmune issues settled down. This improvement in mitochondrial function was a significant turning point in my recovery and I'm looking forward to continued progress."

Mitome customer who improved mitochondrial function and cellular energy with biomarker testing

Anita S.

"The Mitome report’s supplement adjustments have been a game-changer. I used to struggle with frequent colds, a racing heart after caffeine or carbs, and low stress tolerance, which impacted my well-being and focus. Now, my energy is up, my blood sugar is steady, and I feel healthier and more productive overall. I’ve also fallen in love with music again, and my mood has greatly improved."

Smiling customer who improved cellular energy and mitochondrial health using Mitome's mitochondrial function test and biomarker analysis

Nav S.

"I (34M) was a previously healthy 32 year old before I started having a myriad of health issues relating to stopping long term SSRI use. My symptoms were severe and included tachycardia, shortness of breath, neuropathy, sexual dysfunction, anxiety, muscle cramping, numbness, excessive urination. The constellation of symptoms brought me to see dozens of specialists who could not tell me what was going on. I am so grateful I came across Chris' work. Through the analysis, we discovered significant impairments in my mitochondrial electron transport chain, particularly in Complex II and III.

After reviewing my genetic data and mitochondrial function tests, we identified several key areas where my cellular energy production was compromised. Through targeted support of my mitochondrial pathways based on these findings, I quickly began to recover. This is after almost 2 years of being constantly sick. 6 months later, I have regained quality of life and am able to do everything I used to be able to. I am so thankful for Chris and his ability to discern how mitochondrial dysfunction can undermine many medical conditions. When I received the final report, he provided a clear protocol on how to improve my cellular energy production. I continue to improve weekly and am so excited for the future."

Satisfied Mitome customer celebrating biomarker testing results that improved mitochondrial function and cellular energy production

Miguel G

“It took about six months before I began to notice a major shift—but when it happened, it was profound. Almost overnight, I experienced a complete cessation of the negative emotional states I had lived with for so long—depression, anxiety, and mental fatigue simply stopped. Since that moment, any experience of mental or physical discomfort feels more like an observation than a struggle. This shift has made it much easier for me to relax and stay centered—something that used to be incredibly difficult. Recently, I decided to do a second round of Mitome testing, just over a year after starting the treatment, to see how far my mitochondrial function has come. I'm incredibly glad I repeated the test. I’m deeply grateful to Chris and the entire team who supported me through this journey. Their help has been instrumental in restoring my vitality—and for that, I truly thank them.”

Matt B., Mitome customer who uses mitochondrial function testing for cellular energy optimization

Matt B.

“Great test. Results look great. Comprehensive suggestions to correct any issues are provided.”

Happy customer -  uses Mitome mitochondrial testing to address multiple health issues

Taylor T

“Mitome is my #1 lab testing recommendation and finally a lab testing that makes sense, as it goes straight to the root.”

Silke De Oca testimonial - uses Mitome biomarker testing for health insights and energy optimization

Silke De Oca

"This test can be enormously insightful especially used in conjunction with LLM and other data points (lab results, genetic testing, etc.)! Actionable insights are broad, but the information itself is extremely detailed and helpful for identifying potential bottlenecks in energy optimization!"

Melissa B. testimonial - uses Mitome mitochondria test for health insights and energy optimization

Melissa B.

"You have to start here, otherwise you're spinning your wheels and all your hard earned efforts may be hurting you instead of helping you."

Tracy C. customer who uses mitochondrial function testing for cellular energy optimization

Tracy C.

"It might be the most valuable health insights they have ever received and they wont get the level of detail provided here anywhere else."

Steven K. testimonial - uses Mitome mitochondria testing for health insights and energy optimization

Steven K.

"The Mitome test is a one-of-a-kind evaluation of your mitochondrial function, with concrete recommendations for which nutrients to seek and which to avoid."

Paul P., Mitome customer who uses mitochondrial function testing for cellular energy optimization

Paul P.

"If you've struggled for a long time with multiple health issues, esp involving multiple systems, consider doing the Mitome test. It may give you important insights as to major root causes. It lays out steps to take and how to take them. Be prepared to follow a comprehensive plan of action (which can be challenging, demanding, and costly). You may be asked to buy a lactate meter, which isn't cheap -- I tried to find a way around this, but came to understand its importance and that no, there wasn't a way around it if I want to properly figure things out."

Arnold J. testimonial - uses Mitome mitochondria testing to address multiple health issues

Arnold J.

Welcome to the Mitochondrial Revolution.

We’re done playing small. While others sell surface-level hacks, we go to the source—your mitochondria. Join the first real movement in health.

Mitochondrial Testing Kit | Mitome
Cellular Health for Optimal Energy
Mitochondria Test